Researchers in France conduct a longitudinal follow-up assessment of SARS-CoV-2 spike (S) glycoprotein-specific immunological memory in unvaccinated and vaccinated coronavirus disease 2019 (COVID-19) convalescents. as well as COVID-19-naive vaccinees.
In a recent study that was published in the journal Science Translational Medicine. SARS-CoV-2 infection enhances vaccine-induced immunological memory.
Concerning Hybrid Immunity
The COVID-19 vaccine and prior SARS-CoV-2 infection-induced antibodies provide hybrid immunity protection against SARS-CoV-2. Stronger neutralizing antibodies, stronger memory B- and T-lymphocyte responses, and a lower risk of reinfection and its consequences are all associated with hybrid immunity.
Understanding how this hybrid immunity contributes to immunological memory may be enhanced by evaluating immune responses induced by previous COVID-19 and subsequent vaccinations. Additionally, using this data, it may be possible to prioritize individuals at high risk for COVID-19 booster vaccinations.
End Note
The study found that previous COVID-19 vaccinations increased anti-S titers. In addition, anti-S memory B lymphocyte pool remodeling, which is compatible with enhanced functional protection at mucosal sites, was found to be a characteristic of hybrid immunity.
In terms of serological anti-S titers and neutralizing antibodies, prior SARS-CoV-2 infection and vaccination provided greater immune protection than either alone.
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